2026-10-28 20:21:26,499 - INFO - ================================================================================
2026-10-28 20:21:26,499 - INFO - ASSAY CALIBRATION PIPELINE
2026-10-28 20:21:26,499 - INFO - ================================================================================
2026-10-28 20:21:26,499 - INFO - 
Dataset: f7464c1d-5029-4727-aada-f02c1dc4a03d
2026-10-28 20:21:26,500 - INFO - Input: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/input.csv
2026-10-28 20:21:26,500 - INFO - Output: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output
2026-10-28 20:21:26,500 - INFO - Components: [3]
2026-10-28 20:21:26,500 - INFO - Bootstraps: 20
2026-10-28 20:21:26,500 - INFO - n_jobs: 24
2026-10-28 20:21:26,500 - INFO - 
================================================================================
2026-10-28 20:21:26,500 - INFO - STEP 1: Bootstrap Fitting
2026-10-28 20:21:26,500 - INFO - ================================================================================
2026-10-28 20:24:47,378 - INFO - 
Completed 20 bootstrap iterations
2026-10-28 20:24:47,378 - INFO - 
Using fitted components: ['3c']
2026-10-28 20:24:47,378 - INFO - 
================================================================================
2026-10-28 20:24:47,378 - INFO - STEP 3: Visualization and Export
2026-10-28 20:24:47,378 - INFO - ================================================================================
2026-10-28 20:24:47,383 - INFO - 
Processing 3c...
2026-10-28 20:24:47,383 - INFO -   Valid fits: 20/20
2026-10-28 20:24:47,383 - INFO -   Sample indices: P=0, B=1, G=2, S=3
2026-10-28 20:24:48,753 - INFO -   Valid priors: 20
2026-10-28 20:24:48,753 - INFO -   pct_bootstraps_kept (for LR+/prior computation): 1.0000
2026-10-28 20:24:48,753 - INFO -   Prior (benign-direction, P(Y=1)): 0.187311
2026-10-28 20:24:55,246 - INFO -   Scoreset flipped: False
2026-10-28 20:24:55,247 - INFO -   Using median prior for unified thresholds (method=tavtigian)
2026-10-28 20:25:01,334 - INFO -   Bidirectional auto-detect: 0/20 bootstrap fits flagged (0.0%), threshold=50% -> no override
2026-10-28 20:25:01,334 - INFO -   Final ranges computed: 13 non-empty
2026-10-28 20:25:12,401 - INFO -   Saved visualization: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output/f7464c1d-5029-4727-aada-f02c1dc4a03d_3c_visualization.png
2026-10-28 20:25:12,402 - INFO - 
================================================================================
2026-10-28 20:25:12,402 - INFO - STEP 3b: Per-Variant Evidence Table
2026-10-28 20:25:12,402 - INFO - ================================================================================
2026-10-28 20:25:12,685 - INFO -   Standard evidence assigned to 1621 variants (acmg_mapping_method=tavtigian)
2026-10-28 20:25:12,706 - INFO -   Saved variant table: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output/f7464c1d-5029-4727-aada-f02c1dc4a03d_3c_variants.csv (1621 variants)
2026-10-28 20:25:12,713 - INFO - 
================================================================================
2026-10-28 20:25:12,713 - INFO - STEP 4: Saving Results
2026-10-28 20:25:12,713 - INFO - ================================================================================
2026-10-28 20:25:12,714 - INFO -   Saved calibration: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output/f7464c1d-5029-4727-aada-f02c1dc4a03d_3c_calibration.json
2026-10-28 20:25:12,931 - INFO -   Saved LR values: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output/f7464c1d-5029-4727-aada-f02c1dc4a03d_3c_lr_values.json.gz (0.1 MB)
2026-10-28 20:25:12,935 - INFO -   Saved bootstrap fits: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output/f7464c1d-5029-4727-aada-f02c1dc4a03d_bootstrap_fits.json.gz (0.0 MB)
2026-10-28 20:25:12,936 - INFO - 
================================================================================
2026-10-28 20:25:12,936 - INFO - PIPELINE COMPLETE
2026-10-28 20:25:12,936 - INFO - ================================================================================
2026-10-28 20:25:12,936 - INFO - 
Results saved to: /var/www/html/ExCALIBR/jobs/f7464c1d-5029-4727-aada-f02c1dc4a03d/output
2026-10-28 20:25:12,936 - INFO -   - Calibration: f7464c1d-5029-4727-aada-f02c1dc4a03d_<component>_calibration.json
2026-10-28 20:25:12,936 - INFO -   - LR values: f7464c1d-5029-4727-aada-f02c1dc4a03d_<component>_lr_values.json.gz
2026-10-28 20:25:12,936 - INFO -   - Visualization: f7464c1d-5029-4727-aada-f02c1dc4a03d_<component>_visualization.png
2026-10-28 20:25:12,936 - INFO -   - Variant table: f7464c1d-5029-4727-aada-f02c1dc4a03d_<component>_variants.csv
2026-10-28 20:25:12,936 - INFO -   - Bootstrap fits: f7464c1d-5029-4727-aada-f02c1dc4a03d_bootstrap_fits.json.gz