2026-10-21 15:53:30,017 - INFO - ================================================================================
2026-10-21 15:53:30,018 - INFO - ASSAY CALIBRATION PIPELINE
2026-10-21 15:53:30,018 - INFO - ================================================================================
2026-10-21 15:53:30,018 - INFO - 
Dataset: ae21409f-8780-4db7-8079-7ed3361ae218
2026-10-21 15:53:30,018 - INFO - Input: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/input.csv
2026-10-21 15:53:30,018 - INFO - Output: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output
2026-10-21 15:53:30,018 - INFO - Components: [3]
2026-10-21 15:53:30,018 - INFO - Bootstraps: 20
2026-10-21 15:53:30,018 - INFO - n_jobs: 24
2026-10-21 15:53:30,019 - INFO - 
================================================================================
2026-10-21 15:53:30,019 - INFO - STEP 1: Bootstrap Fitting
2026-10-21 15:53:30,019 - INFO - ================================================================================
2026-10-21 15:55:25,815 - INFO - 
Completed 20 bootstrap iterations
2026-10-21 15:55:25,815 - INFO - 
Using fitted components: ['3c']
2026-10-21 15:55:25,815 - INFO - 
================================================================================
2026-10-21 15:55:25,815 - INFO - STEP 3: Visualization and Export
2026-10-21 15:55:25,815 - INFO - ================================================================================
2026-10-21 15:55:25,822 - INFO - 
Processing 3c...
2026-10-21 15:55:25,822 - INFO -   Valid fits: 20/20
2026-10-21 15:55:25,822 - INFO -   Sample indices: P=0, B=1, G=2, S=3
2026-10-21 15:55:27,345 - INFO -   Valid priors: 20
2026-10-21 15:55:27,346 - INFO -   pct_bootstraps_kept (for LR+/prior computation): 1.0000
2026-10-21 15:55:27,346 - INFO -   Prior (benign-direction, P(Y=1)): 0.098646
2026-10-21 15:55:33,773 - INFO -   Scoreset flipped: False
2026-10-21 15:55:33,773 - INFO -   Using median prior for unified thresholds (method=tavtigian)
2026-10-21 15:55:38,497 - INFO -   Bidirectional auto-detect: 0/20 bootstrap fits flagged (0.0%), threshold=50% -> no override
2026-10-21 15:55:38,497 - INFO -   Final ranges computed: 5 non-empty
2026-10-21 15:55:47,562 - INFO -   Saved visualization: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output/ae21409f-8780-4db7-8079-7ed3361ae218_3c_visualization.png
2026-10-21 15:55:47,564 - INFO - 
================================================================================
2026-10-21 15:55:47,564 - INFO - STEP 3b: Per-Variant Evidence Table
2026-10-21 15:55:47,564 - INFO - ================================================================================
2026-10-21 15:55:47,701 - INFO -   Standard evidence assigned to 499 variants (acmg_mapping_method=tavtigian)
2026-10-21 15:55:47,719 - INFO -   Saved variant table: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output/ae21409f-8780-4db7-8079-7ed3361ae218_3c_variants.csv (499 variants)
2026-10-21 15:55:47,725 - INFO - 
================================================================================
2026-10-21 15:55:47,725 - INFO - STEP 4: Saving Results
2026-10-21 15:55:47,726 - INFO - ================================================================================
2026-10-21 15:55:47,726 - INFO -   Saved calibration: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output/ae21409f-8780-4db7-8079-7ed3361ae218_3c_calibration.json
2026-10-21 15:55:47,967 - INFO -   Saved LR values: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output/ae21409f-8780-4db7-8079-7ed3361ae218_3c_lr_values.json.gz (0.1 MB)
2026-10-21 15:55:47,970 - INFO -   Saved bootstrap fits: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output/ae21409f-8780-4db7-8079-7ed3361ae218_bootstrap_fits.json.gz (0.0 MB)
2026-10-21 15:55:47,971 - INFO - 
================================================================================
2026-10-21 15:55:47,971 - INFO - PIPELINE COMPLETE
2026-10-21 15:55:47,971 - INFO - ================================================================================
2026-10-21 15:55:47,971 - INFO - 
Results saved to: /var/www/html/ExCALIBR/jobs/ae21409f-8780-4db7-8079-7ed3361ae218/output
2026-10-21 15:55:47,971 - INFO -   - Calibration: ae21409f-8780-4db7-8079-7ed3361ae218_<component>_calibration.json
2026-10-21 15:55:47,971 - INFO -   - LR values: ae21409f-8780-4db7-8079-7ed3361ae218_<component>_lr_values.json.gz
2026-10-21 15:55:47,971 - INFO -   - Visualization: ae21409f-8780-4db7-8079-7ed3361ae218_<component>_visualization.png
2026-10-21 15:55:47,971 - INFO -   - Variant table: ae21409f-8780-4db7-8079-7ed3361ae218_<component>_variants.csv
2026-10-21 15:55:47,971 - INFO -   - Bootstrap fits: ae21409f-8780-4db7-8079-7ed3361ae218_bootstrap_fits.json.gz