2026-10-21 11:51:16,729 - INFO - ================================================================================
2026-10-21 11:51:16,729 - INFO - ASSAY CALIBRATION PIPELINE
2026-10-21 11:51:16,729 - INFO - ================================================================================
2026-10-21 11:51:16,729 - INFO - 
Dataset: 6f3ff267-b235-4b7f-a59d-ef99037ad963
2026-10-21 11:51:16,729 - INFO - Input: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/input.csv
2026-10-21 11:51:16,729 - INFO - Output: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output
2026-10-21 11:51:16,729 - INFO - Components: [3]
2026-10-21 11:51:16,730 - INFO - Bootstraps: 20
2026-10-21 11:51:16,730 - INFO - n_jobs: 24
2026-10-21 11:51:16,730 - INFO - 
================================================================================
2026-10-21 11:51:16,730 - INFO - STEP 1: Bootstrap Fitting
2026-10-21 11:51:16,730 - INFO - ================================================================================
2026-10-21 11:52:27,243 - INFO - 
Completed 20 bootstrap iterations
2026-10-21 11:52:27,243 - INFO - 
Using fitted components: ['3c']
2026-10-21 11:52:27,244 - INFO - 
================================================================================
2026-10-21 11:52:27,244 - INFO - STEP 3: Visualization and Export
2026-10-21 11:52:27,244 - INFO - ================================================================================
2026-10-21 11:52:27,248 - INFO - 
Processing 3c...
2026-10-21 11:52:27,248 - INFO -   Valid fits: 20/20
2026-10-21 11:52:27,248 - INFO -   Sample indices: P=0, B=1, G=2, S=3
2026-10-21 11:52:28,621 - INFO -   Valid priors: 20
2026-10-21 11:52:28,621 - INFO -   pct_bootstraps_kept (for LR+/prior computation): 1.0000
2026-10-21 11:52:28,622 - INFO -   Prior (benign-direction, P(Y=1)): 0.161006
2026-10-21 11:52:35,398 - INFO -   Scoreset flipped: False
2026-10-21 11:52:35,398 - INFO -   Using median prior for unified thresholds (method=tavtigian)
2026-10-21 11:52:40,115 - INFO -   Bidirectional auto-detect: 0/20 bootstrap fits flagged (0.0%), threshold=50% -> no override
2026-10-21 11:52:40,116 - INFO -   Final ranges computed: 12 non-empty
2026-10-21 11:52:50,179 - INFO -   Saved visualization: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output/6f3ff267-b235-4b7f-a59d-ef99037ad963_3c_visualization.png
2026-10-21 11:52:50,180 - INFO - 
================================================================================
2026-10-21 11:52:50,181 - INFO - STEP 3b: Per-Variant Evidence Table
2026-10-21 11:52:50,181 - INFO - ================================================================================
2026-10-21 11:52:50,239 - INFO -   Standard evidence assigned to 115 variants (acmg_mapping_method=tavtigian)
2026-10-21 11:52:50,245 - INFO -   Saved variant table: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output/6f3ff267-b235-4b7f-a59d-ef99037ad963_3c_variants.csv (115 variants)
2026-10-21 11:52:50,249 - INFO - 
================================================================================
2026-10-21 11:52:50,249 - INFO - STEP 4: Saving Results
2026-10-21 11:52:50,249 - INFO - ================================================================================
2026-10-21 11:52:50,250 - INFO -   Saved calibration: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output/6f3ff267-b235-4b7f-a59d-ef99037ad963_3c_calibration.json
2026-10-21 11:52:50,479 - INFO -   Saved LR values: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output/6f3ff267-b235-4b7f-a59d-ef99037ad963_3c_lr_values.json.gz (0.1 MB)
2026-10-21 11:52:50,483 - INFO -   Saved bootstrap fits: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output/6f3ff267-b235-4b7f-a59d-ef99037ad963_bootstrap_fits.json.gz (0.0 MB)
2026-10-21 11:52:50,483 - INFO - 
================================================================================
2026-10-21 11:52:50,483 - INFO - PIPELINE COMPLETE
2026-10-21 11:52:50,483 - INFO - ================================================================================
2026-10-21 11:52:50,483 - INFO - 
Results saved to: /var/www/html/ExCALIBR/jobs/6f3ff267-b235-4b7f-a59d-ef99037ad963/output
2026-10-21 11:52:50,483 - INFO -   - Calibration: 6f3ff267-b235-4b7f-a59d-ef99037ad963_<component>_calibration.json
2026-10-21 11:52:50,483 - INFO -   - LR values: 6f3ff267-b235-4b7f-a59d-ef99037ad963_<component>_lr_values.json.gz
2026-10-21 11:52:50,483 - INFO -   - Visualization: 6f3ff267-b235-4b7f-a59d-ef99037ad963_<component>_visualization.png
2026-10-21 11:52:50,484 - INFO -   - Variant table: 6f3ff267-b235-4b7f-a59d-ef99037ad963_<component>_variants.csv
2026-10-21 11:52:50,484 - INFO -   - Bootstrap fits: 6f3ff267-b235-4b7f-a59d-ef99037ad963_bootstrap_fits.json.gz