2026-10-21 11:36:21,566 - INFO - ================================================================================
2026-10-21 11:36:21,566 - INFO - ASSAY CALIBRATION PIPELINE
2026-10-21 11:36:21,566 - INFO - ================================================================================
2026-10-21 11:36:21,566 - INFO - 
Dataset: 4ad0d34d-1259-47f9-b880-f2f02098c549
2026-10-21 11:36:21,566 - INFO - Input: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/input.csv
2026-10-21 11:36:21,567 - INFO - Output: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output
2026-10-21 11:36:21,567 - INFO - Components: [3]
2026-10-21 11:36:21,567 - INFO - Bootstraps: 20
2026-10-21 11:36:21,567 - INFO - n_jobs: 24
2026-10-21 11:36:21,567 - INFO - 
================================================================================
2026-10-21 11:36:21,567 - INFO - STEP 1: Bootstrap Fitting
2026-10-21 11:36:21,567 - INFO - ================================================================================
2026-10-21 11:37:30,940 - INFO - 
Completed 20 bootstrap iterations
2026-10-21 11:37:30,941 - INFO - 
Using fitted components: ['3c']
2026-10-21 11:37:30,941 - INFO - 
================================================================================
2026-10-21 11:37:30,941 - INFO - STEP 3: Visualization and Export
2026-10-21 11:37:30,941 - INFO - ================================================================================
2026-10-21 11:37:30,945 - INFO - 
Processing 3c...
2026-10-21 11:37:30,946 - INFO -   Valid fits: 20/20
2026-10-21 11:37:30,946 - INFO -   Sample indices: P=0, B=1, G=2, S=3
2026-10-21 11:37:32,482 - INFO -   Valid priors: 20
2026-10-21 11:37:32,482 - INFO -   pct_bootstraps_kept (for LR+/prior computation): 1.0000
2026-10-21 11:37:32,482 - INFO -   Prior (benign-direction, P(Y=1)): 0.161006
2026-10-21 11:37:38,772 - INFO -   Scoreset flipped: False
2026-10-21 11:37:38,772 - INFO -   Using median prior for unified thresholds (method=tavtigian)
2026-10-21 11:37:43,613 - INFO -   Bidirectional auto-detect: 0/20 bootstrap fits flagged (0.0%), threshold=50% -> no override
2026-10-21 11:37:43,614 - INFO -   Final ranges computed: 12 non-empty
2026-10-21 11:37:53,679 - INFO -   Saved visualization: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output/4ad0d34d-1259-47f9-b880-f2f02098c549_3c_visualization.png
2026-10-21 11:37:53,681 - INFO - 
================================================================================
2026-10-21 11:37:53,681 - INFO - STEP 3b: Per-Variant Evidence Table
2026-10-21 11:37:53,681 - INFO - ================================================================================
2026-10-21 11:37:53,741 - INFO -   Standard evidence assigned to 115 variants (acmg_mapping_method=tavtigian)
2026-10-21 11:37:53,749 - INFO -   Saved variant table: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output/4ad0d34d-1259-47f9-b880-f2f02098c549_3c_variants.csv (115 variants)
2026-10-21 11:37:53,752 - INFO - 
================================================================================
2026-10-21 11:37:53,752 - INFO - STEP 4: Saving Results
2026-10-21 11:37:53,752 - INFO - ================================================================================
2026-10-21 11:37:53,753 - INFO -   Saved calibration: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output/4ad0d34d-1259-47f9-b880-f2f02098c549_3c_calibration.json
2026-10-21 11:37:53,966 - INFO -   Saved LR values: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output/4ad0d34d-1259-47f9-b880-f2f02098c549_3c_lr_values.json.gz (0.1 MB)
2026-10-21 11:37:53,969 - INFO -   Saved bootstrap fits: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output/4ad0d34d-1259-47f9-b880-f2f02098c549_bootstrap_fits.json.gz (0.0 MB)
2026-10-21 11:37:53,970 - INFO - 
================================================================================
2026-10-21 11:37:53,970 - INFO - PIPELINE COMPLETE
2026-10-21 11:37:53,970 - INFO - ================================================================================
2026-10-21 11:37:53,970 - INFO - 
Results saved to: /var/www/html/ExCALIBR/jobs/4ad0d34d-1259-47f9-b880-f2f02098c549/output
2026-10-21 11:37:53,970 - INFO -   - Calibration: 4ad0d34d-1259-47f9-b880-f2f02098c549_<component>_calibration.json
2026-10-21 11:37:53,970 - INFO -   - LR values: 4ad0d34d-1259-47f9-b880-f2f02098c549_<component>_lr_values.json.gz
2026-10-21 11:37:53,970 - INFO -   - Visualization: 4ad0d34d-1259-47f9-b880-f2f02098c549_<component>_visualization.png
2026-10-21 11:37:53,970 - INFO -   - Variant table: 4ad0d34d-1259-47f9-b880-f2f02098c549_<component>_variants.csv
2026-10-21 11:37:53,970 - INFO -   - Bootstrap fits: 4ad0d34d-1259-47f9-b880-f2f02098c549_bootstrap_fits.json.gz